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Archive - Apr 25, 2015

Staggering Evolutionary Breadth of Exosomes Is a Theme of Saturday’s Session of ISEV 2015 Annual Meeting in DC

Saturday’s session of the 2015 Annual Meeting of the International Society for Extracellular Vesicles (ISEV) (http://www.isevmeeting.org/), April 23-26 in Washington, DC, opened with three early-morning “Meet the Experts” sessions. These highly valuable sessions offer any of the 800-plus meeting attendees the opportunity to both hear the background and latest news in a particular research area, as delivered by world leaders in that area, but then also to ask questions of these experts. These sessions typically provide a tremendous source of information exchange on key advancing areas in exosome research. One of the three sessions was entitled “Bacterial and Parasite EVs,” and offered exciting information from two of the world leaders in such studies. After a brief introduction by Dr. Pamela Wearsch, herself an expert in Mycobacterium tuberculosis, Dr. Yong Song Gho, a professor at POSTECH, Korea, editor-in-chief of the ISEV’s highly successful, three-year-old Journal of Extracellular Vesicles (JEV), and a 15-year veteran of studying exosomes in bacteria stepped to the microphone to describe some of his seminal work in this area. Dr. Gho first described work done by others in the 1960s to identify what were then called outer membrane vesicles (OMVs) that were produced and released by gram(-) bacteria. After their initial discovery, these OMVs were found everywhere there were gram(-) bacteria and that is essentially everywhere. With regard to the function(s) of the OMVs, there were suggestions that they aided bacterial survival, that they played a role in nutrient sensing, that they might modulate the immune response of the host, and that they might also influence the ABC transporter. Dr.