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Archive - Apr 17, 2018

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IDA-Wisconsin Holds Annual Conference on Dyslexia

Almost 90 attendees from all over Wisconsin, and also from Illinois and Minnesota, journeyed through rough winter weather conditions to attend a conference organized by the Wisconsin Branch of the International Dyslexia Association (IDA) (http://wi.dyslexiaida.org/), and held in the Wisconsin Dells on Saturday, April 14, 2018. The theme of the conference was “Moving Literacy Forward Until Everyone Can Read.” Attendees included teachers, tutors, parents, some who are afflicted by dyslexia, and vendors who provide products to aid those with dyslexia. Conference sponsors included the Walbridge School in Madison, Wisconsin; Mount St. Joseph University; and the 2017 IDA Reading, Literacy & Learning Conference Audio Recordings. The Walbridge School (http://walbridgeschool.org/) was founded in 1984 by educators and parents in order to meet the academic, social, and emotional needs of children who learn differently. Mount St. Joseph University is a Cincinnati-based educational institute that offers a fully online reading science program (http://www.msj.edu/academics/graduate-programs/master-of-arts-teacher-ad...). Session recordings with slide decks from the IDA's Reading, Literacy & Learning Conference in November 2017 are now available for purchase at www.dyslexiaida.org. Vendors at this year’s conference included IDA-Wisconsin, Decoding Dyslexia Wisconsin, Mount St. Joseph, Silver Moon Spelling Rules, Sylvan Spirit Pqbd Jewelry, Waldbridge School, School Specialty Instruction & Intervention, and Project Success UW-Oshkosh.

Immunotherapy (Keytruda), When Combined with Chemotherapy, Doubles Survival Time of Patients with Metastatic Lung Cancer

The immunotherapy drug pembrolizumab (Keytruda), when combined with chemotherapy, doubles survival in patients with non-squamous non-small cell lung cancer (NSNSCLC) lacking genetic changes in the EGFR or ALK genes, when compared to chemotherapy alone, according to results of an international phase III clinical trial. Principal investigator Leena Gandhi, MD, PhD, Director of the Thoracic Medical Oncology Program at Perlmutter Cancer Center at New York University (NYU Langone Health and associate professor of medicine in the Division of Medical Oncology at New York University (NYU) School of Medicine, presented these findings April 16, 2018 at the American Association for Cancer Research (AACR) Annual Meeting in Chicago. The data from this study were simultaneously published online on April 16, 2018 in the New England Journal of Medicine. The open-access article is titled “Combination of Pembrolizumab & Chemotherapy Doubles Survival in Patients with Metastatic Lung Cancer.” A total of 616 patients with untreated metastatic NSNSCLC without EGFR or ALK alterations, from 118 international sites, were randomly allocated for the trial—405 patients were treated with both pembrolizumab and platinum therapy plus pemetrexed, and 202 received platinum therapy plus pemetrexed with a saline placebo. Response rates, overall survival, and progression-free survival rates were superior in the pembrolizumab and chemotherapy combination treatment group. In the press release provided here and below, see a video of Dr.

How Plants Avoid DNA Damage from UV Light--Nobel Laureate Aziz Sancar’s Lab Reveals First-Ever Repair Map of an Entire Multicellular Organism to Illuminate Inner Workings of Plant Kingdom's Highly Efficient DNA Repair System

If the ultraviolet radiation from the sun damages human DNA to cause health problems, does UV radiation also damage plant DNA? The answer is yes, but because plants can't come in from the sun or slather on sunblock, they have a super robust DNA repair kit. Today, the Unversity of North Carolina (UNC) School of Medicine lab of 2015 Nobel laureate Aziz Sancar, MD, PhD, has published an exquisite study of this powerful DNA repair system in plants, which closely resembles a repair system found in humans and other animals. The study, published online on April 17, 2018 in Nature Communications, is the first repair map of an entire multicellular organism. It revealed that the "nucleotide excision repair" system works much more efficiently in the active genes of plants as compared to humans. And this efficiency depends on the day/night cycle. The open-access Nature Comminications article is titled “Genome-Wide Excision Repair in Arabidopsis Is Coupled to Transcription and Reflects Circadian Gene Expression Patterns.” "These findings advance our understanding of DNA repair mechanisms common among all organisms and may also have practical applications," said co-corresponding author Ogun Adebali, PhD, a postdoctoral researcher in the Sancar lab. First author Onur Oztas, PhD, a postdoctoral researcher in the Sancar lab, said, "DNA damage accumulating in a plant will impair its growth and development, so boosting the excision repair system could be a good strategy for improving crop yields." Dr.