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Archive - Jul 11, 2020

Date

International Society for Extracellular Vesicles (ISEV) 2020 Virtual Annual Meeting, Including Exosomes, July 20-22: Plenary Speakers, Panel Sessions, Featured Abstracts, Oral Abstract Talks, Poster Chats, & Educational Sessions; FOCUS: FEATURED ABSTRACTS

The International Society for ExtracellularVesicles (ISEV) AnnualMeeting (ISEV2020), Including #Exosomes, Is Now VIRTUAL (July 20-22); and will feature over 600 Discussions (Plenary Addresses, Panel Sessions, Featured Abstracts, Oral Abstract Talks, Poster Chats, & Educational Sessions). The program can viewed here (https://www.isev.org/mpage/2020Program) and registration can be done here (https://www.isev.org/mpage/2020Registration). As eminent Yale Professor Philip Askenase, MD, has said, “Exosomes are a sensational biologic discovery and they seem to be involved in nearly all biological and clinical processes.” Among its myriad stimulating and timely offerings, the ISEV 2020 virtual meeting will include 12-minute oral presentations of four Featured Abstracts that have been selected for their high quality and significance. Featured Abstracts 1 and 2 will be presented on Monday, June 20; Featured Abstract 3 will be presented on Tuesday, June 21; and Featured Abstract 4 will be presented on Wednesday, June 22. Each Featured Abstract presentation will be followed by a 5-minute Q&A session, moderated by a leader in the field. Featured Abstract 1 is titled “Ral GTPases Promote Metastasis By Controlling Biogenesis and Organotropism of Extracellular Vesicles,” and will be presented by Shima Ghoroghi, from Dr. Jacky Goetz’s Lab for Tumor Biomechanics, University of Strasbourg, France. Featured Abstract 2 is titled “Towards Reference Intervals of Extracellular Vesicles in Human Plasma by Flow Cytometry,” and will be presented by Bo Li, Southern Medical University, Guangzhou, China.

Circadian Clocks of Individual Cells: Two New Studies from Dr. Joseph Takahashi’s Lab at UTSW Suggest Cellular Rhythms Are Guided by Both Heritable and Nonheritable Components; Researchers Focus on Long-Period (28 Hours) & Short-Period Cells (21 Hours)

Two new studies led by University of Texas (UT) Southwestern (UTSW) scientists outline how individual cells maintain their internal clocks, driven both through heritable and random means. These findings, published online on May 1, 2020 in PNAS (https://www.pnas.org/content/117/19/10350 ) and on May 27, 2020 in eLife (https://elifesciences.org/articles/54186), help explain how organisms’ circadian clocks maintain flexibility and could offer insights into aging and cancer. The open-access PNAS article is titled "Noise-Driven Cellular Heterogeneity in Circadian Periodicity" and the open-access eLife article is titled "Epigenetic Inheritance of Circadian Period in Clonal Cells." Scientists have long known that organisms across the spectrum of life have internal clocks--with cycles about as long as a day--that govern behaviors including sleeping, eating, and immune response. However, individual cells also have their own clocks when removed from the organism, with periods that can vary substantially, stretching up to several hours longer or shorter. How cells maintain these different lengths of internal rhythms has been unknown given that these cells should be the same at the genetic level, explains Joseph Takahashi (photo) (https://profiles.utsouthwestern.edu/profile/105885/joseph-takahashi.html), PhD, Professor and Chair of the Department of Neuroscience at UT Southwestern Medical Center, a member of UTSW’s Peter O’Donnell Jr. Brain Institute, and an Investigator with the Howard Hughes Medical Institute. To investigate this question, Dr. Takahashi and his colleagues worked with mouse cells that were genetically altered so that they glowed whenever a prominent circadian clock gene called Per2 was turned on.