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Idol Enzyme Seizes Spotlight in Cholesterol Control

In a mouse system, UCLA researchers have identified an enzyme (Idol) that orchestrates the breakdown of LDL receptors and results in higher levels of LDL (“bad cholesterol”) in the blood stream. By blocking Idol’s activity, the researchers triggered cells to make more LDL receptors and to remove more LDL from the body. Statin drugs also reduce LDL levels by boosting cells' production of the LDL receptor. The current findings could lead to a new drug that works in conjunction with statins, or that could be taken by patients who cannot tolerate statins' side effects. "We only know of three pathways that regulate the LDL receptor. The first two are already targeted by existing drugs," explained Dr. Peter Tontonoz, senior author of the report. "Idol is the first mechanism discovered in several years that may lead to a new medication designed to control cholesterol levels." The work was published in the June 11 online edition of Science. [Press release] [Science abstract]