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Beta Cell Growth, Insulin Production Increased in Diabetic Mice

By “knocking out” the Lkb1 gene in the beta cells of diabetic laboratory mice, scientists have been able to increase the size and number of beta cells and also to increase the amount of insulin stored in and released by these cells. “We were surprised by the impressive accumulation of Lkb1 in beta cells of diabetic mice, which suggested that Lkb1 might contribute to their impaired function. After removal of the Lkb1 gene, the beta cells grow larger, proliferate more, and secrete more insulin. It's a one-stop shop for the much needed insulin", said Dr. Robert Screaton, senior author of the research report. Importantly, the improved beta cell function lasted for at least five months, even in mice fed a high-fat diet designed to mimic the high caloric intake associated with metabolic syndrome and type 2 diabetes in humans. "The knockout mice on a high-fat diet have lower blood glucose. If this observation is confirmed in humans, it may give us another clue into the development of type 2 diabetes, and perhaps new treatment options,” Dr. Screaton said. This work was published in the October 7 issue of Cell Metabolism. [Press release] [Cell Metabolism abstract]