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Origins of Deadly Prostate Cancer Traced to Single Aberrant Cell

The origins of metastatic prostate cancer cells can be traced to a single original cancer cell in individuals. This is the conclusion of a 14-year autopsy-based study of copy number variation in the cells of prostate cancer victims. The study was carried out by researchers at Johns Hopkins and collaborating institutions. The findings call into question current views of the origins of primary prostate cancer and suggest that the genomic profile of prostate cancer metastases should inform therapeutic decisions. [Press release] [Nature Medicine abstract]