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Closing Ceremony of 2015 Annual Meeting of the International Society for Extracellular Vesicles (ISEV) Features Awards, Research Summary, Clinical Summary, and On to Rotterdam in 2016!

At the end of Dr. Gary Ruvkun’s plenary address, Dr. Jan Lötvall, President of the International Society for Extracellular Vesicles (ISEV) (, stepped forward to chair the closing ceremony of this “exciting and most interesting” 2015 annual ISEV meeting. First, Dr. Lötvall introduced Andy Hill, Ph.D., Professor and Department Head at the La Trobe Institute for Molecular Sciences at La Trobe University in Melbourne, Australia, to present a “wrap-up” of the scientific research presented at the meeting. Dr. Hill highlighted a number of areas of keen interest. These included EV biogenesis, isolation and characterization of EVs/exosomes, vesicle labeling, imaging (including super-resolution, confocal, intravital, and EM microscopy), nomenclature, and transcriptomics/RNA analysis. He also emphasized the great success of this year’s newly added “Meet the Experts” sessions. Next, Dr. Lötvall introduced Louise Laurent, M.D., Ph.D., an Assistant Professor, an obstetrician specializing in high-risk pregnancies, and a prominent EV researcher from the University of California, San Diego (UCSD), to give a wrap-up of the meeting from a clinical perspective. Dr. Laurent began by outlining where we are today, which she said is at the stage of discovering biomarkers and determining mechanisms, and where we are going in the future, which she said is in the direction of identifying druggable targets that might be EV-based and enable further development of personalized medicine. She emphasized that clinical progress in this area will depend critically on collaborations and cross-talk to speed advances. Communication needs to be “reciprocal,” she said, not “sequential.” Dr. Laurent also highlighted the needs for increased standardization and concern for reproducibility. She emphasized that early involvement with regulatory bodies is another critical factor in advancing research into the clinic. Finally, she noted that this was her very first ISEV annual meeting and that it had been a truly “wonderful experience.”

Next, Dr. Lötvall and Dr. Marca Wauban, ISEV Chair of Science and Meetings, resumed the stage and made the much-anticipated announcement of where the 2016 ISEV annual meeting would be held. And the answer was Rotterdam, which had very successfully hosted the 2014 ISEV annual meeting. Next year’s ISEV annual meeting will begin on May 4.

Next, Ken Witwer (photo), Ph.D., Assistant Professor at Johns Hopkins, who works in the HIV/exosome area and who was chair of the local organizing committee for this 2015 ISEV annual meeting, stepped forward to thank a number of key people and also to present twelve awards for outstanding oral and poster presentations given in the course of the four-day conference.

Dr. Witwer also noted that almost 500 abstracts (487) were presented at the meeting and that 65 of these were late-breaking. In addition, he observed that the pre-meeting Education Day had experienced an impressive 50% increase in attendance over that for the same event at the previous year’s annual meeting.

Awards for oral presentations were presented to Simona Principe for “Exosomal Cargo to Identify Targets within the Tumor Microenvironment,” Susanne G. van der Grein for “Immunogenic and Tolerogenic Dendritic Cell Subsets Release Phenotypically Different EV Populations with Distinct Immune Modulatory Properties,” Hina Kalra for “EVs Containing Mutant Beta-Catenin Activate Wnt Signaling Pathway in the Tumor Microenvironment,” and Edwin van der Pol for “Quantitative Light Scattering of EVs for Flow Cytometry Standardization.”

Then, in the category of poster and oral presentations, where individuals both presented their poster and also gave a brief oral summary of it to a plenary audience, awards were given to Michelle Hung for “Engineered Glycosylation Stabilizes Exosomes-Targeting Peptides and Enables Targeted Exosomes Delivery” and to Stefania Raimondo for “Isolation and Characterization of Citrus limon L.-Derived Nanovesicles—Potential Use As Anti-Neoplastic Agent.”

Finally, in the category of poster presentations, awards were presented to Gagan Deep for “Hypoxia-Induced Lipid Accumulation in Prostate Cancer Cells Controls EV Biogenesis Promoting Growth and Invasiveness,” Christina Schindler for “Optimization of Exosome Loading with Cytotoxic Small Molecule Drug Doxorubicin by Electroporation,” Janet Digby for “Endothelial-Derived EVs in Inflammation Stimulate Monocyte Migration in vitro and This Is Mediated by Endoglin/CD105,” Wei-Ting Hung for “Follicular Fluid EVs Regulate Cumulus-Oocyte Complex Expansion through Preferential Uptake by Cumulus Cells,” Uma Muthukrishnan for “Stress-Induced Changes in Exosomal Histone Secretion,” and Anuradha Kalani for “Embryonic Stem Cell Exosomes-Encapsulated Curcumin; Novel Therapy for Cerebral Ischemia in Type-1 Diabetes Mellitus.”

Dr. Witwer thanked the numerous volunteers who had contributed greatly to the extremely smooth running of the entire conference. He also expressed sincere thanks to the nine-member local organization board that had done so much to facilitate this fantastic meeting. He had the entire board come up on stage for additional, well-deserved, public recognition.

In turn, Dr. Lötvall briefly interrupted to express his belief that Dr. Witwer himself had done a truly “amazing job.” And certainly no one in the room would disagree. The organization and running of this jam-packed conference was simply superbly handled.

Dr. Lötvall also expressed his great appreciation to the sponsors who had played such a major role in making this fabulous meeting possible.

These sponsors included the Gold sponsors: BD, Invitrogen by Thermo Fisher Scientific, iZON Science, JSR Life Sciences, and Particle Metrix; the Silver sponsors: Beckman Coulter Life Sciences and System Biosciences (SBI); and the Bronze sponsors: Apogee, Hansa Bio Med, Hitachi Chemical, Malvern, New England Peptide (nep), Norgen Biotek Corp., Qiagen, and ‘TORAY’ Innovation by Chemistry.

And finally, Dr. Lötvall thanked all the attendees noting that “you are so fantastic; you are the ISEV.”

“Safe travels home and see you next year in Rotterdam!”