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UCLA Scientists Show Rare Coding Variants Affecting Protein Function Are More Common in Schizophrenics; Results Support Origin of Schizophrenia During Early Stages of Brain Development

A new study by UCLA scientists adds to the understanding of the genetic architecture of schizophrenia. Past research has shown the impact of commonly occurring genetic variants on a person’s risk of developing schizophrenia. This new study focused instead on rare coding mutations that affect protein function. It found that people with schizophrenia have a higher-than-normal share of these mutations. “While we cannot point to specific mutations that play a causal role in schizophrenia, we show that schizophrenia patients, collectively, have more of these mutations than unaffected individuals,” said Dr. Loes Olde Loohuis, the study’s first author and a postdoctoral fellow at UCLA’s Center for Neurobehavioral Genetics. The Center is part of the UCLA’s Jane and Terry Semel Institute for Neuroscience and Human Behavior. The findings were published online on July 9, 2015 in an open-access article in Nature Communications. The article is titled “Genome-Wide Burden of Deleterious Coding Variants Increased in Schizophrenia.” “Genes that are affected by these mutations play a key role in fetal brain development,” said Dr. Roel Ophoff, the study’s senior author and a principal investigator at the Center for Neurobehavioral Genetics. “Our finding further supports the hypothesis that schizophrenia is a disorder that may originate during the early stages of brain development.” A professor of psychiatry and human genetics, Dr. Ophoff has conducted research on the genetic basis of schizophrenia for the past decade. He is also one of the founding members of the Psychiatric Genomics Consortium’s schizophrenia study group. The consortium is an international collaboration of researchers investigating the genetics of schizophrenia and related disorders.

Schizophrenia affects some 2 million to 3 million people in the U.S. — approximately 1 percent of the population. It is characterized by hallucinations, delusions, and disorganization, and can take a tremendous toll on patients and their families. Schizophrenia can cause a significant loss in quality of life, including unemployment and estrangement from loved ones. A better understanding of the causes of the disease may lead to better options for treating it.

Dr. Ophoff and his colleagues used an array-based technology to screen for 250,000 DNA coding variants in more than 1,000 schizophrenia patients from the Netherlands and compared these samples to those from unaffected individuals. They found that the patients with schizophrenia had more of these variants than patients without schizophrenia. The researchers confirmed these findings in another cohort consisting of more than 13,000 schizophrenia patients and control subjects from the U.K.

“Even though it’s well-known that schizophrenia has a large genetic component, the specific biological mechanisms at work are not well understood,” Dr. Ophoff said. “Our research shows that rare coding variants throughout the human genome also contribute to this complex genetic architecture.”

The study’s other UCLA-affiliated authors were Dr. Rita Cantor, Professor in Residence in Human Genetics; Dr. Anil Ori, Staff Researcher at the Center for Neurobehavioral Genetics; and Dr. Kim Staats, Postdoctoral Scholar at the Semel Institute. The team also included researchers from University Medical Center Utrecht, in the Netherlands; and the MRC Centre for Psychiatric Genetics and Genomics at Cardiff University, in Wales.

[Press release] [Nature Communications article]