Syndicate content

Research Shows Different Growth Rates in Two Pygmy Populations Despite Similar Adult Heights; Different Mechanisms at Work; Scientists Conclude That Human Growth Rates Can Change and Evolve Rapidly

While the stature of pygmies is well-suited to tropical rainforests, the mechanisms underlying their growth remain poorly understood. In order to decipher these mechanisms, a team of scientists from the CNRS (Laboratoire Dynamique de l'Evolution Humaine), IRD (Laboratoire Patrimoines Locaux et Gouvernance) and UPMC1 (Centre de Recherche Saint-Antoine) studied a group of Baka pygmies in Cameroon. Their findings revealed that the Baka pygmy growth rate differed completely from that of another pygmy cluster, despite a similar adult height, which implies that small stature appeared independently in the two clusters. This work was published online on July 28, 2015 in an open-accerss article in Nature Communications. The article is titled “Growth Pattern from Birth to Adulthood in African Pygmies of Known Age.” The stature of pygmies has intrigued Westerners since their first encounter with them in 1865. This population is, in fact, made up of several ethnic groups, which belong to two main clusters. One is spread across Equatorial West Africa (Congo, Cameroon, Gabon, Central African Republic, and Western DRC) while the other is found in East Africa, in Eastern DRC and Rwanda. They all live in forested regions, linked with Bantu farmers. Although genetic factors are responsible for the small stature of pygmies, until now, scientists were unable to produce reliable data on their age in order to analyze their growth patterns. Thanks to the registers of the Catholic mission in Moange-le-Bosquet, Cameroon, it was possible, in the current research, to study 500 members of the Baka ethnic group for eight years in order to establish the first growth curves for pygmies. The scientists were thus able to show that although the body size at birth of the Baka was within normal limits, their growth rate then slowed significantly until the age of three years. Their growth curves subsequently paralleled global standards, with a growth spurt at adolescence and an adult size achieved on average at the same time as that seen throughout the world. However, they never made up for this initial retardation. On the other hand, pygmies in the eastern cluster were born with a smaller body size, so that their small stature resulted from growth processes different from those of the Baka.

The pygmy morphology of these populations thus results from two different mechanisms, which may be linked to an imbalance between the growth hormone and the two IGF2s that has allowed them to adapt to rainforest conditions, under a mechanism of convergent evolution.

These pygmy clusters thus split apart between 8,000 and 13,000 years ago, which shows that human growth can evolve within a relatively short period of time. This growth plasticity may have played a determining role in the spread of Homo sapiens outside Africa, allowing this species to adapt rapidly to new environments.

These findings also highlight the fact that further longitudinal studies (i.e., the monitoring of individuals over time) are needed to enhance the research in genetics and endocrinology that is necessary to shed light on the growth mechanisms in play amongst pygmies, as well as in the rest of the world's population, in whom they are also poorly understood.

The scientists now wish to determine the endocrine processes that cause the growth deceleration observed during infancy in the Baka, by identifying the hormones and cellular structures that are responsible for this particular growth pattern, targeting the underlying genes and comparing them with those found in East African pygmies.

For more information, please view a documentary film made by Laurent Maget and produced by CNRS Images and IRD: "Pygmées Baka, le grand Virage.”

The image shows a group of adult pygmies with Charles Knowles, founder of the Wildlife Conservation Network. Knowles was not involved with the research described here.

[Press release] [Nature Communications article]