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Acquisition of Four Key Gut Bacteria (FLVR) by 3 Months of Age May Reduce Risk of Childhood Asthma

New research by scientists at the University of British Columbia (UBC) and British Columbia Children's Hospital finds that infants may be protected from developing asthma if they acquire four types of gut bacteria by three months of age. The research was published in the September 30, 2015 issue of Science Translational Medicine and the article is titled “Early Infancy Microbial and Metabolic Alterations Affect Risk of Childhood Asthma.” More than 300 families from across Canada participated in this research through the Canadian Healthy Infant Longitudinal Development (CHILD) Study. "This research supports the hygiene hypothesis that we're making our environment too clean. It shows that gut bacteria play a role in asthma, but it is early in life when the baby's immune system is being established," said the study's co-lead researcher Dr. B. Brett Finlay, Peter Wall Distinguished Professor in the Michael Smith Laboratories and the Departments of Microbiology & Immunology and Biochemistry and Molecular Biology at UBC. Asthma rates have increased dramatically since the 1950s and now affect up to 20 per cent of children in western countries. This discovery opens the door to developing probiotic treatments for infants that might prevent asthma. The finding could also be used to develop a test for predicting which children are at risk of developing asthma. In the study, the researchers analyzed fecal samples from 319 children involved in the CHILD Study. Analysis of the gut bacteria from the 319 samples revealed lower levels of four specific gut bacteria in three-month-old infants who were at an increased risk for asthma. Most babies naturally acquire these four bacteria, nicknamed FLVR (Faecalibacterium, Lachnospira, Veillonella, Rothia), from their environments, but some do not, either because of the circumstances of their birth or other factors.

The researchers also found fewer differences in FLVR levels among one-year-old children, suggesting that the first three months are a critical time period for a baby's developing immune system.

The researchers confirmed these findings in mice and also discovered that newborn mice inoculated with the FLVR bacteria developed less severe asthma.

"This discovery gives us new potential ways to prevent this disease that is life-threatening for many children. It shows there's a short, maybe 100-day window for giving babies therapeutic interventions to protect against asthma," said co-lead researcher Dr. Stuart Turvey, Pediatric Immunologist, BC Children's Hospital, Director of Clinical Research and Senior Clinician Scientist at the Child & Family Research Institute, and Aubrey J. Tingle Professor of Pediatric Immunology at UBC.

The researchers say that further study with a larger number of children is required to confirm these findings and reveal how these bacteria influence the development of asthma.

Note that a video describing this research is available and can be accessed via the link provided below.

Also note the links to multiple popular press articles on this new research.

[Press release] [Science Translational Medicine abstract] [Video]

[CBC News article] [ScienceNews article] [Discover Magazine article] [SF Gate/AP article] [WebMDs article] [Denver Post article] [Medscape article] [Medical News Today article]