Syndicate content

Cough Medicine Ingredient Shows Promise for Prostate Cancer Treatment

Researchers have shown that, in mice, the cough medicine ingredient noscapine inhibits prostate tumor growth and also limits the spread of tumors without causing any side-effects. Noscapine, a non-addictive derivative of opium, has been used worldwide since the 1950s as an ingredient in over-the-counter cough medicines and was originally suggested as an anti-cancer agent in the early 1960s--but major studies of its anti-cancer properties have only taken place in recent years. The current research focused on pre-treating mice with noscapine before injecting them with prostate cancer cells. This resulted in the tumor growth rate being two-thirds lower in the noscapine group than in a non-noscapine group. The study also found that metastasis rates to the lung were 80 percent lower in the mice pre-treated with noscapine. The scientists further noted that the noscapine group suffered no cancer-related weight loss--compared with significant weight loss in the non-noscapine group. They concluded that noscapine administered as a preventive measure may offer significant benefits in the management of prostate cancer, a disease that kills more than 28,000 men in the U.S. each year. The research team is now hoping to further its efforts by examining the effects of noscapine as a prophylactic agent given to patients following prostate cancer surgery or radiation. "Based on our research so far, we believe that noscapine could be a very promising treatment to prevent recurrence in such cases due to its excellent safety record and oral bioavailability," said co-author Dr. Israel Barker, Founder and Medical Director of the Prostate Cancer Research and Education Foundation. This new pre-clinical research was reported in Volume 30(2) of Anticancer Research. [Press release] [Anticancer Research]