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Preventive Therapy for Type 1 Diabetes Shows Promise

Scientists in Australia have shown that use of a particular molecule (BCMA) that blocks the action of a B-cell survival hormone (BAFF) may provide a potential preventive therapy for type 1 diabetes. Working with mice that spontaneously develop type 1 diabetes, the researchers found that if BAFF activity was blocked prior to onset of the disease, none of the mice developed diabetes. "This is a remarkable finding, as other B-cell depletion methods tested elsewhere have just delayed or reduced disease incidence," said one of the authors of the study. By removing B-cells from the picture for a while, the researchers indicated, it appears the T regulatory cells are allowed to function as they should, subduing killer T-cells and somehow making them tolerant of the insulin-producing cells in the pancreas. The blocking molecule (BCMA) is already being used in clinical trials for other autoimmune diseases. The research was published online in Diabetes. [Press release]