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Specific Gene Types Driving Higher Frequency of Myeloma Diagnosis in African-Americans Identified By Mayo Clinic Researchers; DNA Sequencing Used to More Accurately Determine Racial Ancestry; Findings May Aid Insight into Best Forms of Therapy

Researchers at the Mayo Clinic in Rochester, Minnesota, have identified three specific gene types that account for a known two-to-three-fold increase in myeloma diagnoses among African-Americans. Researchers also demonstrated the ability to study race and racial admixture more accurately using DNA analysis. The findings were published online on October 10, 2018 in Blood Cancer Journal. The open-access article is titled “Differences in Genomic Abnormalities Among African Individuals with Monoclonal Gammopathies Using Calculated Ancestry.” "Myeloma is a serious blood cancer that occurs two to three times more often in African-Americans than Caucasians," says Vincent Rajkumar(photo), MD. a hematologist at the Mayo Clinic and senior author of the study. "We sought to identifying the mechanisms of this health disparity to help us better understand why myeloma occurs in the first place and provide insight into the best forms of therapy." Dr. Rajkumar and his colleagues studied 881 patients of various racial groups. Researchers found that the higher risk of myeloma known to occur in African-Americans was driven by three specific subtypes of the cancer characterized by the presence of genetic translocations in cancer cells. Translocations are genetic abnormalities in cancer cells caused by the rearrangement of parts between nonhomologous chromosomes. The translocation researchers identified were t(11;14), t(14;16), and (t14;20). "Previous efforts to understand this disparity have relied on self-reported race rather than on genetic ancestry, which may have resulted in bias," explains Dr. Rajkumar. "A major new aspect of this study is that we identified the ancestry of each patient through DNA sequencing, which allowed us to determine ancestry more accurately." Dr. Rajkumar says the probability of an individual having one of the three specific translocations responsible for myeloma was significantly higher in the 120 patients who researchers identified with the highest level of African ancestry compared to the 235 individuals identified with lowest level of African ancestry.

"There are efforts to enroll more minorities in clinical studies, and this is important.," says Dr. Rajkumar. "However, it is equally, if not more important, to determine the mechanisms of racial disparities in terms of why cancers occur more often in certain racial groups. Our findings provide important information that will help us determine the mechanism by which myeloma is more common in African-Americans, as well as help us in our quest to find out what causes myeloma in the first place."

Dr. Rajkumar says study results also are important because response to cancer treatments vary based on the genetic subtype of cancer, and these findings will help researchers develop more effective treatment strategies for African-Americans with myeloma.

[Press release] [Blood Cancer Journal]