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Genetic Roots of Animal Tameness Discovered in Rats

In breeding studies conducted in rats, an international team of researchers has identified genomic regions associated with tameness. The discovery could help animal breeders, farmers, zoologists, and anyone else who handles and raises animals to more fully understand what makes some animals interact with humans better than do others. It may also lead to more precise breeding strategies designed to pass specific genes from one generation to the next as a way to produce tame animals. “I hope our study will ultimately lead to a detailed understanding of the genetics and biology of tameness," said Dr. Frank Albert, the lead author of the research report. "Maybe we'll then be able to domesticate a few of those species where humans have historically not been successful, like the wild African Buffalo." For this study, two groups of rats, one bred for tameness toward humans and the other bred for aggressiveness toward humans, were mated with each other and genomic regions associated with tameness and with aggressiveness were identified. The senior author of this study was Dr. Svante Paabo. The research was published in the June issue of Genetics. [Press release] [Genetics abstract]